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ChandlerBing a dit:Et certains nootropiques tels que la théanine, la centella asiatica... ont des mécanismes d'actions sur le cerveau très similaire à certaines drogues/antidépresseurs ( qui eux ont pour fonction avoué de créer le bonheur artificiellement/partiellement )
Centella asiatica is a herb used since ancient times in Ayurveda to improve cognitive functioning. The current study aimed at managing the cognitive decline in elderly with mild cognitive impairment (MCI) and other age related problems. MCI is a serious problem which may be converted into Alzheimer disease. Although the concept of MCI is based on the presence of specific cognitive deficits, several studies show that these subjects can develop depression, disruptive behavior (e.g agitation, aggression). The present study was conducted in sixty elderly subjects with written consent obtained, registered at the geriatric out patient clinic at S.S. Hospital, BHU aged 65 and above. The Diagnostic tools used in this study were Mini Mental State Examination, Activities of Daily Living, Instrumental Activities of Daily living and Yesavage Geriatric Depression scale. The Centella asiatica extract was prescribed in dosage of 500mg twice a day (1000 mg daily) for 6 months. A favorable improvement is observed in cognitive functioning, depression and other age related conditions like Hypertension, insomnia, loss of appetite, constipation etc.
Antidepressant properties:
The antidepressant effects of total triterpenes from CA (Centella Asiatica, au cas où vous avez pas suivi) on the immobility time in forced swimming mice and concentration of amino acid in mice brain tissue was observed. In the study, imipramine and total triterpenes from CA reduced the immobility time and ameliorated the imbalance of amino acid levels confirming the antidepressant activity of CA[29]. The same authors investigated the possible antidepressant effect of total triterpentes of CA by measuring the corticosterone levels in mice brain[30]. The contents of monoamine neurotransmitters and their metabolites in rats cortex, hippocampus and thalamus were evaluated wherein significant reduction of the corticosterone level and increase of the contents of 5-HT, NE, DA and their metabolites 5-HIAA, MHPG in rat brain were observed which further strengthened the postulated involvement of total triterpenes of CA in ameliorating the function of HPA axis and increasing the contents of monoamine neurotransmitters for its antidepressant effects.
Antiepileptic properties:
Asian CA increases the cerebral levels of GABA, which explains its traditional use as anxiolytic and anticonvulsant. The isolated steroids from the plant have been used to treat leprosy[31]. In one study, the effects of aqueous CAE (100 and 300 mg/kg) were evaluated on the course of kindling development, kindling-induced learning deficit and oxidative stress markers in pentylenetetrazole (PTZ) kindled rats[32]. Passive avoidance test and spontaneous locomotor activity, after 24 and 48 h after administration of PTZ, and oxidative stress parameters like malondialdehyde (MDA) and glutathione were carried out in the whole brain of animals. The administration of CA (300 mg/kg, p.o) decreased the PTZ-kindled seizures and showed improvement in the learning deficit induced by PTZ kindling as evidenced by decreased seizure score and increased latencies in passive avoidance behaviour. The findings suggested the potential of aqueous CAE as adjuvant to antiepileptic drugs with an added advantage of preventing cognitive impairment. The hydroalcoholic extract of CA leaves was also subjected to pharmacological screening using various experimental models and was found to show protective action against increase in intracranial electric stimulation (ICES) and chemo-convulsions, which includes pentylenetetrazol-induced convulsions, pentylenetetrazol-kindled seizures, and strychnine-induced opisthotonus tonic convulsions on oral administration[33]. It also showed a reduction in formation of lipid peroxidation products, reduction in spontaneous motor activity, potentiation in diazepam withdrawal-induced hyperactivity, hypothermia, and potentiation of pentobarbitone sleeping time. The extract (200 mg/kg body weight) completely inhibited pentylenetetrazol-induced convulsions. In pentylenetetrazol-kindled seizures and strychnine-induced convulsions, the extract showed protection at a dose of 100 mg/kg body weight. The doses of the extract selected for remaining studies were based on pilot studies, animal model used, and so forth. These findings suggested its potential anticonvulsant as well as antioxidant, and CNS depressant actions.
Extrait normalisé (capsules ou comprimés – non disponible au Canada). Prendre 60 mg, d’une à trois fois par jour. Seul ce type d'extrait, aussi désigné sous le nom de « fraction triterpénique totale de Centella asiatica » (TTFCA), a fait l'objet d'études concluantes. Il est normalisé à 40 % d'asiaticoside, de 29 % à 30 % d'acide asiatique, de 29 % à 30 % d'acide madécassique et de 1 % à 2 % de madécassoside.
Tissu a dit:...De là à dire qu'il faudrait la déconseiller aux dépressifs mineurs j'irai pas dans cette direction vu les effets AD démontrés, et notament vu aussi les effets très positifs qu'en a eu le Chapelier au cours de son sevrage.
Tissu a dit:.
On peut pour autant éviter de se sentir mou en accompagnant cet apport d'une consommation parallèle de caféine dont l'effet va être tempéré par la théanine, mais en y ajoutant une potentialisation bénéfique favorisant le mental et la concentration...