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Holofractale de l'hypervérité
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Nootropiques : Les nootropiques (de noos esprit et tropos courber) sont des drogues et des médicaments qui changent la pensée. Plus spécifiquement, le terme réfère à une vue qui fait écho à la campagne de publicité « vivre mieux par la chimie ». Les nootropiques sont promus dans le transhumanisme comme un moyen général d'améliorer les conditions de vie, ou pour des buts spécifiques, comme d'augmenter la motivation.
Boooh commencer en citant wikipédia, on n'a connu mieux je vous l'accordent.
Bon un petit cours de rattrapage vu que l'on en parlent pas beaucoup par ici:
Tout d'abord les éléments de base, si je puis dire. La choline, substance qui devrais accompagner tout consommateur de nootropic ( sauf les bipolaire parait il ).
La choline a plusieurs sources dont la lechitine ( dosé entre 5 et 8gr reparti 3 fois par jours), ou alpha GPC ( 1 à 2 gr/jours).
Elle devrait être accompagné de 1 gr de Vitamine B5/jours. ( transformation en acetyl-choline ).
Maintenant on composent!
Des dizaines de substances sont classées ( parfois à la hâte, parfois par motivations mercantiles ) Nootropic.
Passages en revue de quelques une:
Piracetam: 2-oxo-Pyrrolidine Acetamide.
Le plus répandu des -racetam, le moins puissant aussi. Analogue du GABA, procure une sensation d'éveil, anti oxydant, 2 à 6g/jours.
Certains auront besoin d'une forte doses pour activer le mécanisme, 7/8g.
Aniracetam: 1-Anisoyl-2-pyrrolidinone.
Grand frère, plus puissant même propriétés avec un effet anxiolytique plus prononcé, 800mg à 1,6g/jours.
Oxiracetam: 4-hydroxy-2-oxo-1-pyrrolidinacetamide
Plus fort, plus beau, la classe a ca qu'il paraît...
800mg à 1,6g/jours.
Pramiracetam: N-{2-(diisopropylamino)ethyl}-2-oxo-1-pyrrolidine-acetamide
Si ani est le grand frère lui c'est le daron...le plus fort. 100mg à 300mg/jours.
Hydergine: ergoloid mesylates
Ca ne vous rappellent rien? Hoffman, Sandoz...
Ralenti le processus de vieillissement, augmente les facultés mentales, 6 à 12mg/jours.
Theanine:
Acide aminé du thé vert, se transforme en GABA. 200 à 1000mg/jours. contre l'anxiété...
La théanine est dérivée de l’acide aminé la glutamine ce qui lui favorise l’accès aux cellules du cerveau, où elle joue un rôle de psychotrope.
L’activité de la théanine sur le cerveau a montré une réduction du stress mental et physique et produit un effet relaxant.
Le mécanisme d’action de la théanime semble provenir de sa capacité à favoriser la production d'Acide gamma-aminobutyrique (GABA) et donc sa concentration. La théanine semble augmenter la concentration de sérotonine, de dopamine et a des affinités avec les récepteurs AMPA, Kainate et NMDA.
L’injection de théanine chez des souris souffrant d'hypertension a montré une diminution significative du 5-hydroxyindole dans le cerveau.
La théanine augmente la production du rythme alpha dans le cerveau.
Vasopressine:
Améliore mémoire, concentration, attention.
Pour les consommateur de stimulants type coc/amphét...il parait que cela peut aider a récupérer la forme après les prises.
Vinpocetine: Ethyl Apovincamine
Anti oxydant, amélioration de l'humeur, concentration...20 à 40mg/jours pendant le repas.
Acide bêta-phényl-gamma-aminobutyrique
Anti oxydant, anxiolitique, forte accoutumance ( ce n'est pas vraiment un nootropic selon moi ). 1 à 2 gr/jours
Acetyl-L-Carnitine
Dosage: 250 à 500mg/jours utilisations brèves, 100 à 200mg/jours utilisations continu. Attention-deficit hyperactivity disorder (ADHD): Only one study has examined the effects of L-carnitine in boys with ADHD. Although results were promising, additional study is needed before a strong recommendation can be made.
Grade: C
AIDS: Carnitine may be beneficial in AIDS treatment by increasing proliferation of mononuclear cells and increasing CD4 counts. Additional study is needed to make a firm recommendation.
Grade: C
Alcoholism: L-carnitine or acetyl-L-carnitine may be of benefit to alcoholics. Additional study is needed to make a firm recommendation.
Grade: C
Alzheimer's disease: Early evidence suggests the effectiveness of L-carnitine and/or acetyl-L-carnitine for Alzheimer's disease. However, the evidence is mixed.
Grade: C
Arrhythmia (abnormal heart rhythms): Although preliminary results are promising, there is insufficient available evidence to recommend for or against this use.
Grade: C
Cerebral ischemia (lack of adequate blood flow to the brain): There are a limited number of studies showing a positive effect of L-acetyl-carnitine on cerebral blood flow and metabolism of the brain in patients who have suffered from stroke. Additional study is required before a firm recommendation can be made.
Grade: C
Congestive heart failure: Although preliminary results are promising, there is insufficient available evidence to recommend for or against the use of carnitine for congestive heart failure.
Grade: C
Dementia (elderly): Most of the studies related to dementia suffer from various weaknesses. Although preliminary evidence is promising, there is insufficient available evidence to recommend for or against this use.
Grade: C
Depression: Although preliminary evidence is promising, there is insufficient available evidence to recommend for or against the use of carnitine in the treatment of depression.
Grade: C
Diabetes mellitus: It has been suggested that L-carnitine under constant infusion is able to increase insulin sensitivity in patients with diabetes mellitus type II and enhance glucose oxidation. Carnitine may also decrease fasting blood glucose and Lp(a). Additional study is needed before a firm recommendation can be made.
Grade: C
Diabetic neuropathy: Early evidence suggests that acetyl-L-carnitine may be beneficial for individuals with diabetic neuropathy. Additional study is needed before a firm recommendation can be made.
Grade: C
Erectile dysfunction: Preliminary studies suggest that propionyl-L-carnitine, with acetyl-L-carnitine or sildenafil may be beneficial for patients with erectile dysfunction. However, more rigorous trials should be performed in order to recommend carnitine for routine use in erectile dysfunction.
Grade: C
Exercise performance: Overall, the data is mixed in terms of the benefits of L-carnitine for exercise performance. Until confirmed, a strong recommendation for L-carnitine cannot be made for increased exercise endurance.
Grade: C
Fatigue: There are several promising reports on the use of L-carnitine for fatigue. However, additional study is warranted in this area.
Grade: C
Hepatic encephalopathy (brain disease): Preliminary evidence suggests L-carnitine may be of benefit to individuals with hepatic encephalopathy, in terms of ammonia levels and psychometric functioning. Additional study is needed to make a firm recommendation.
Grade: C
Infertility (asthenospermia): Early evidence shows a positive effect for carnitine and/or acetyl-L-carnitine in terms of increased sperm motility. However, additional study is needed before a firm conclusion can be made.
Grade: C
Memory: There are a limited number of studies relevant to the use of carnitine for memory. Carnitine does not appear to have any effect on memory. Additional study is needed before a firm recommendation can be made.
Grade: C
Myocardial infarction (heart attack): Currently there is insufficient evidence to support the use of carnitine for myocardial infarction. Additional study is needed in this area.
Grade: C
Nutritional deficiencies (adults): Currently there is insufficient evidence to support the use of carnitine in the total parenteral nutrition for adults. Additional study is needed in this area.
Grade: C
Nutritional deficiencies (full term infants): Despite a large number of studies, it is not clear what effect, if any, the addition of carnitine has on weight gain in full term infants. Additional study is needed.
Grade: C
Nutritional deficiencies (premature infants): Despite a large number of studies, it is not clear what effect, if any, the addition of carnitine has on weight gain in premature infants. Additional study is needed.
Grade: C
Obesity: Early evidence shows that L-carnitine may have no effect on weight loss in obese patients. Further studies are needed before a firm recommendation can be made.
Grade: C
Peripheral neuropathy (nerve damage): Currently there is insufficient evidence to support the use of carnitine for peripheral neuropathy.
Grade: C
Peripheral vascular disease: Propionyl-L-carnitine and L-carnitine may treat peripheral vascular disease, especially in patients with severe limitations in peripheral circulation. The comparative effectiveness of propionyl-L-carnitine and other recognized treatments is unclear. More study is needed to make a firm recommendation.
Grade: C
Peyronie's disease: Although early evidence is promising, more study is needed before a firm recommendation can be made.
Grade: C
Pregnancy (miscarriage): Currently there is insufficient evidence to support the use of carnitine for miscarriage.
Grade: C
Respiratory distress (adults): Currently there is insufficient evidence to support the use of carnitine for respiratory distress in adults.
Grade: C
Respiratory distress (infants): Currently there is insufficient evidence to support the use of carnitine for respiratory distress in infants.
Grade: C
Rett's syndrome: There are promising results on the use of carnitine for this condition. Before a strong recommendation can be made, additional well-designed trials are needed.
Grade: C
Sickle cell disease: Preliminary evidence suggests the absence of any therapeutic effect of propionyl-L-carnitine for sickle cell disease. Additional studies are required before a firm recommendation can be made.
Grade: C
Surgerical uses (bypass): The results of studies on the use of carnitine in improving the functioning of myocardium (heart muscle) during open-heart surgery are controversial. Currently, there is insufficient available evidence to recommend for or against the use of carnitine.
Grade: C
DHEA: déhydroépiandrostérone
Dosage: 50 à 2000mg/jours
DHEA, abréviation de la déhydroépiandrostérone est une molécule qui fait partie de la famille des stéroïdes. Isolée en 1931 par Butenandt, dans les urines, elle fait l'objet de dosages précis vers la fin des années 50. Ces recherches ont permis de confirmer sa diminution avec l'âge. Le Professeur Etienne-Emile Beaulieu découvre en 1960 que cette hormone est secrétée par les glandes corticosurrénales, sous forme de sulfate de DHEA.
L'action de la DHEA, rapportée en 2000 par l'étude DHEAge[1], a montré une amélioration des propriétés mécanique de la peau et de la densité osseuse, uniquement chez les femmes âgées de 70 ans ou davantage. Une amélioration de la libido a été également constatée. Ses bénéfices ne sont pas confirmés par d'autres données, ne relevant aucune amélioration sur plusieurs paramètres, dont la qualité de vie[2]
La DHEA n'est actuellement pas en vente libre en France, les autorités sanitaires Française (AFSSAPS) ayant décidé de poursuivre son évaluation avant de donner son autorisation de mise sur le marché. Il est facile de se la procurer par Internet dans des pays comme les États-Unis où elle est commercialisée depuis les années 1990 en tant que simple complément alimentaire.
DHEA is involved in protecting brain neurons from senility-associated degenerative conditions like Alzheimer's disease. Not only does the neuronal degenerative condition occur most frequently at the time of lowest DHEA levels, but brain tissue contains more DHEA than is found in the bloodstream. In an experiment with brain cell tissue cultures, Dr. Eugene Roberts found that very low concentrations of DHEA were found to "increase the number of neurons, their ability to establish contacts, and their differentiation." DHEA also enhanced long-term memory in mice undergoing avoidance training. Perhaps it plays a similar role in human brain function.
DOSAGE of DHEA ranges from 50 mg to 2000 mg per day. There is no solid information indicating an optimal dosage for humans, but, if you want to get serious, you can get your DHEA levels checked every few months (for about $65), each time raising the amount of DHEA you take. When your blood levels reach what is normal for a 20-year-old human, then you're taking enough.
là, ce n'est qu'un aperçu, il en existent plein d'autres, je ne les connais pas tous ( pour l'instant ), il y a aussi, DHEA, DMAE, arcoline...
L'apport en concentration, le brouillard qui se lève plus vite le matin ( avis aux fumeurs ), l'humeur qui s'améliore, les propriétés anxiolytiques, la neurotoxicité nulle, l'accoutumance faible, sont des facteurs qui pourraient en intéressé certains ici je pense.
Le sujet à été abordé rapidement ici, il y a quelques temps, nouvelle mode, les drogues qui rendent intelligent etc...les termes étaient peu élogieux, cependant elles méritent que vous révisiez votre jugement, pour ceux qui était présent, et que les autres fassent connaissances...!
Boooh commencer en citant wikipédia, on n'a connu mieux je vous l'accordent.
Bon un petit cours de rattrapage vu que l'on en parlent pas beaucoup par ici:
Tout d'abord les éléments de base, si je puis dire. La choline, substance qui devrais accompagner tout consommateur de nootropic ( sauf les bipolaire parait il ).
La choline a plusieurs sources dont la lechitine ( dosé entre 5 et 8gr reparti 3 fois par jours), ou alpha GPC ( 1 à 2 gr/jours).
Elle devrait être accompagné de 1 gr de Vitamine B5/jours. ( transformation en acetyl-choline ).
Maintenant on composent!
Des dizaines de substances sont classées ( parfois à la hâte, parfois par motivations mercantiles ) Nootropic.
Passages en revue de quelques une:
Piracetam: 2-oxo-Pyrrolidine Acetamide.
Le plus répandu des -racetam, le moins puissant aussi. Analogue du GABA, procure une sensation d'éveil, anti oxydant, 2 à 6g/jours.
Certains auront besoin d'une forte doses pour activer le mécanisme, 7/8g.
Aniracetam: 1-Anisoyl-2-pyrrolidinone.
Grand frère, plus puissant même propriétés avec un effet anxiolytique plus prononcé, 800mg à 1,6g/jours.
Oxiracetam: 4-hydroxy-2-oxo-1-pyrrolidinacetamide
Plus fort, plus beau, la classe a ca qu'il paraît...
800mg à 1,6g/jours.
Pramiracetam: N-{2-(diisopropylamino)ethyl}-2-oxo-1-pyrrolidine-acetamide
Si ani est le grand frère lui c'est le daron...le plus fort. 100mg à 300mg/jours.
Hydergine: ergoloid mesylates
Ca ne vous rappellent rien? Hoffman, Sandoz...
Ralenti le processus de vieillissement, augmente les facultés mentales, 6 à 12mg/jours.
Theanine:
Acide aminé du thé vert, se transforme en GABA. 200 à 1000mg/jours. contre l'anxiété...
La théanine est dérivée de l’acide aminé la glutamine ce qui lui favorise l’accès aux cellules du cerveau, où elle joue un rôle de psychotrope.
L’activité de la théanine sur le cerveau a montré une réduction du stress mental et physique et produit un effet relaxant.
Le mécanisme d’action de la théanime semble provenir de sa capacité à favoriser la production d'Acide gamma-aminobutyrique (GABA) et donc sa concentration. La théanine semble augmenter la concentration de sérotonine, de dopamine et a des affinités avec les récepteurs AMPA, Kainate et NMDA.
L’injection de théanine chez des souris souffrant d'hypertension a montré une diminution significative du 5-hydroxyindole dans le cerveau.
La théanine augmente la production du rythme alpha dans le cerveau.
Vasopressine:
Améliore mémoire, concentration, attention.
Pour les consommateur de stimulants type coc/amphét...il parait que cela peut aider a récupérer la forme après les prises.
Vinpocetine: Ethyl Apovincamine
Anti oxydant, amélioration de l'humeur, concentration...20 à 40mg/jours pendant le repas.
Acide bêta-phényl-gamma-aminobutyrique
Anti oxydant, anxiolitique, forte accoutumance ( ce n'est pas vraiment un nootropic selon moi ). 1 à 2 gr/jours
Acetyl-L-Carnitine
Dosage: 250 à 500mg/jours utilisations brèves, 100 à 200mg/jours utilisations continu. Attention-deficit hyperactivity disorder (ADHD): Only one study has examined the effects of L-carnitine in boys with ADHD. Although results were promising, additional study is needed before a strong recommendation can be made.
Grade: C
AIDS: Carnitine may be beneficial in AIDS treatment by increasing proliferation of mononuclear cells and increasing CD4 counts. Additional study is needed to make a firm recommendation.
Grade: C
Alcoholism: L-carnitine or acetyl-L-carnitine may be of benefit to alcoholics. Additional study is needed to make a firm recommendation.
Grade: C
Alzheimer's disease: Early evidence suggests the effectiveness of L-carnitine and/or acetyl-L-carnitine for Alzheimer's disease. However, the evidence is mixed.
Grade: C
Arrhythmia (abnormal heart rhythms): Although preliminary results are promising, there is insufficient available evidence to recommend for or against this use.
Grade: C
Cerebral ischemia (lack of adequate blood flow to the brain): There are a limited number of studies showing a positive effect of L-acetyl-carnitine on cerebral blood flow and metabolism of the brain in patients who have suffered from stroke. Additional study is required before a firm recommendation can be made.
Grade: C
Congestive heart failure: Although preliminary results are promising, there is insufficient available evidence to recommend for or against the use of carnitine for congestive heart failure.
Grade: C
Dementia (elderly): Most of the studies related to dementia suffer from various weaknesses. Although preliminary evidence is promising, there is insufficient available evidence to recommend for or against this use.
Grade: C
Depression: Although preliminary evidence is promising, there is insufficient available evidence to recommend for or against the use of carnitine in the treatment of depression.
Grade: C
Diabetes mellitus: It has been suggested that L-carnitine under constant infusion is able to increase insulin sensitivity in patients with diabetes mellitus type II and enhance glucose oxidation. Carnitine may also decrease fasting blood glucose and Lp(a). Additional study is needed before a firm recommendation can be made.
Grade: C
Diabetic neuropathy: Early evidence suggests that acetyl-L-carnitine may be beneficial for individuals with diabetic neuropathy. Additional study is needed before a firm recommendation can be made.
Grade: C
Erectile dysfunction: Preliminary studies suggest that propionyl-L-carnitine, with acetyl-L-carnitine or sildenafil may be beneficial for patients with erectile dysfunction. However, more rigorous trials should be performed in order to recommend carnitine for routine use in erectile dysfunction.
Grade: C
Exercise performance: Overall, the data is mixed in terms of the benefits of L-carnitine for exercise performance. Until confirmed, a strong recommendation for L-carnitine cannot be made for increased exercise endurance.
Grade: C
Fatigue: There are several promising reports on the use of L-carnitine for fatigue. However, additional study is warranted in this area.
Grade: C
Hepatic encephalopathy (brain disease): Preliminary evidence suggests L-carnitine may be of benefit to individuals with hepatic encephalopathy, in terms of ammonia levels and psychometric functioning. Additional study is needed to make a firm recommendation.
Grade: C
Infertility (asthenospermia): Early evidence shows a positive effect for carnitine and/or acetyl-L-carnitine in terms of increased sperm motility. However, additional study is needed before a firm conclusion can be made.
Grade: C
Memory: There are a limited number of studies relevant to the use of carnitine for memory. Carnitine does not appear to have any effect on memory. Additional study is needed before a firm recommendation can be made.
Grade: C
Myocardial infarction (heart attack): Currently there is insufficient evidence to support the use of carnitine for myocardial infarction. Additional study is needed in this area.
Grade: C
Nutritional deficiencies (adults): Currently there is insufficient evidence to support the use of carnitine in the total parenteral nutrition for adults. Additional study is needed in this area.
Grade: C
Nutritional deficiencies (full term infants): Despite a large number of studies, it is not clear what effect, if any, the addition of carnitine has on weight gain in full term infants. Additional study is needed.
Grade: C
Nutritional deficiencies (premature infants): Despite a large number of studies, it is not clear what effect, if any, the addition of carnitine has on weight gain in premature infants. Additional study is needed.
Grade: C
Obesity: Early evidence shows that L-carnitine may have no effect on weight loss in obese patients. Further studies are needed before a firm recommendation can be made.
Grade: C
Peripheral neuropathy (nerve damage): Currently there is insufficient evidence to support the use of carnitine for peripheral neuropathy.
Grade: C
Peripheral vascular disease: Propionyl-L-carnitine and L-carnitine may treat peripheral vascular disease, especially in patients with severe limitations in peripheral circulation. The comparative effectiveness of propionyl-L-carnitine and other recognized treatments is unclear. More study is needed to make a firm recommendation.
Grade: C
Peyronie's disease: Although early evidence is promising, more study is needed before a firm recommendation can be made.
Grade: C
Pregnancy (miscarriage): Currently there is insufficient evidence to support the use of carnitine for miscarriage.
Grade: C
Respiratory distress (adults): Currently there is insufficient evidence to support the use of carnitine for respiratory distress in adults.
Grade: C
Respiratory distress (infants): Currently there is insufficient evidence to support the use of carnitine for respiratory distress in infants.
Grade: C
Rett's syndrome: There are promising results on the use of carnitine for this condition. Before a strong recommendation can be made, additional well-designed trials are needed.
Grade: C
Sickle cell disease: Preliminary evidence suggests the absence of any therapeutic effect of propionyl-L-carnitine for sickle cell disease. Additional studies are required before a firm recommendation can be made.
Grade: C
Surgerical uses (bypass): The results of studies on the use of carnitine in improving the functioning of myocardium (heart muscle) during open-heart surgery are controversial. Currently, there is insufficient available evidence to recommend for or against the use of carnitine.
Grade: C
DHEA: déhydroépiandrostérone
Dosage: 50 à 2000mg/jours
DHEA, abréviation de la déhydroépiandrostérone est une molécule qui fait partie de la famille des stéroïdes. Isolée en 1931 par Butenandt, dans les urines, elle fait l'objet de dosages précis vers la fin des années 50. Ces recherches ont permis de confirmer sa diminution avec l'âge. Le Professeur Etienne-Emile Beaulieu découvre en 1960 que cette hormone est secrétée par les glandes corticosurrénales, sous forme de sulfate de DHEA.
L'action de la DHEA, rapportée en 2000 par l'étude DHEAge[1], a montré une amélioration des propriétés mécanique de la peau et de la densité osseuse, uniquement chez les femmes âgées de 70 ans ou davantage. Une amélioration de la libido a été également constatée. Ses bénéfices ne sont pas confirmés par d'autres données, ne relevant aucune amélioration sur plusieurs paramètres, dont la qualité de vie[2]
La DHEA n'est actuellement pas en vente libre en France, les autorités sanitaires Française (AFSSAPS) ayant décidé de poursuivre son évaluation avant de donner son autorisation de mise sur le marché. Il est facile de se la procurer par Internet dans des pays comme les États-Unis où elle est commercialisée depuis les années 1990 en tant que simple complément alimentaire.
DHEA is involved in protecting brain neurons from senility-associated degenerative conditions like Alzheimer's disease. Not only does the neuronal degenerative condition occur most frequently at the time of lowest DHEA levels, but brain tissue contains more DHEA than is found in the bloodstream. In an experiment with brain cell tissue cultures, Dr. Eugene Roberts found that very low concentrations of DHEA were found to "increase the number of neurons, their ability to establish contacts, and their differentiation." DHEA also enhanced long-term memory in mice undergoing avoidance training. Perhaps it plays a similar role in human brain function.
DOSAGE of DHEA ranges from 50 mg to 2000 mg per day. There is no solid information indicating an optimal dosage for humans, but, if you want to get serious, you can get your DHEA levels checked every few months (for about $65), each time raising the amount of DHEA you take. When your blood levels reach what is normal for a 20-year-old human, then you're taking enough.
là, ce n'est qu'un aperçu, il en existent plein d'autres, je ne les connais pas tous ( pour l'instant ), il y a aussi, DHEA, DMAE, arcoline...
L'apport en concentration, le brouillard qui se lève plus vite le matin ( avis aux fumeurs ), l'humeur qui s'améliore, les propriétés anxiolytiques, la neurotoxicité nulle, l'accoutumance faible, sont des facteurs qui pourraient en intéressé certains ici je pense.
Le sujet à été abordé rapidement ici, il y a quelques temps, nouvelle mode, les drogues qui rendent intelligent etc...les termes étaient peu élogieux, cependant elles méritent que vous révisiez votre jugement, pour ceux qui était présent, et que les autres fassent connaissances...!
Je n'avais aucune idée de tout ça... La neurotoxicité est vraiment nulle? Je veux dire, combien de recul on a par rapport à tout ça..?
