2-methyl-2-butanol could be the best alternative to ethanol (ethyl alcohol) for regular use. It creates no toxic aldehydes, has no hangover, is more euphoric, more social and with nearly no side effects or loss of coordination at 2 to 6 mL. 5 to 8mL makes the user sleepy. 8mL or less seem safe. It has an extensive past and has been used medicinally. It could be the alternative that could be used the most frequently if it were very easily available.
2C-x chemicals seem interesting because they have some effects at sub-hallucinogenic doses. 2C-C at low doses could be relaxing. 2C-I at low doses are energetic. 2C-D at low doses improves memory. Maybe mixing one 2C-x with another 2C-x at low doses to get the low dose effects of both. 2C chemicals may hold powerful nootropic potential.
MDxx chemicals (MDMA, MDEA, MDPR , MDPH, ect.) could be the once monthly alternative some people would try. It would be the best one ever, even if it can't be used often. The precautions like staying hydrated with water and electrolytic drinks, keeping the room very cool, taking quercetin with it to rewiden constricted blood vessels due to MDxx, taking 5-HTP and Tryptophan afterwards to replace the precursors to serotonin and help serotonin build back up in the brain faster. Spacing the time between each roll, ect. It's extremely fun and you throw a rave at someone's house and dance for hours while the energy and warmth flows throughout your body.