Hi, it is an SSRI, so yes, it can have dire interactions with DMT and Ayahuasca, any reputable facilitator in the Amazon will not let you take part if you're taking anti-depressants, especially these.
It is highly, highly advisable to avoid any and all psychedelics if you're taking SSRIs.
And, whilst I fully understand your friend is likely experiencing a difficult time mentally and emotionally, if they can find other ways to deal with it other than anti-depressants it would be advisable.
They don't cure anything, they only mask, and often times don't even do that well. SSRI are well known to cause suicidal thoughts in many, they have terrible side effects both coming on them, during and most notably coming off them. Just do a few searches on withdraw symptoms and that brand or any other SSRI and you'll see.
Your friend would be much better of seeing a psychotherapist or a host of other interventions before resorting to using a chemical crutch.
If they do decide to take that route, psychs and mind altering substances are off the menu, seriously not advisable to mix them up.