Homer gets a prescription for marijuana. Marge is troubled, the kids bemused, but Homer, who indulges as expected, is also conflicted. His remedy: "Do as I say, not as I do."
In other episodes, Homer...
* Has insomnia and watches a late night TV commercial for "Nappien," which "won't cause foot-fattening or elbow stink."
* Takes expired medication he finds in a neighbor's trash. When Marge tells him to stop, he says, "But Marge, what if I'm not getting enough ... [glances at label] ... estrogen!"
* Invents a drink — the Flaming Homer, a.k.a. the Flaming Moe — in which the main ingredient is children's cough syrup.
* Gets the entire town of Springfield high when he distributes a beverage made from carrots and peyote.
* Takes another man's medications while visiting his father in the nursing home. Grandpa comments, "The pink ones keep you from screaming."
* Gets high on cleaning-chemical fumes and hallucinates that he's being attacked by Scrubbing Bubbles, Mr. Clean, and other characters.
* As he and Ned Flanders drive to Las Vegas, they pass a car driven by a warped and hallucinating Hunter S. Thompson as drawn by Ralph Steadman.
And of course, Homer's fondness for Duff beer is legendary.
I bolded my favorite thing on there. Fear and Loathing in Las Vegas is an EXCELLENT book.