The effects of maternal THC abuse on young rats

[Caduceus Mercurius]

I really wish scientists would be allowed to start studying psychedelics like psilocybine, DMT and LSD as much as they are now studying cannabinoids. And I also wish they would stop giving these substances to animals.

In any case, DoseNation reported on the results of a study investigating the effects of THC on brain development in young rats:

Marijuana toxicity in young rats
A reasonably respectable German study shows that:

"There is strong evidence that THC, the main psychoactive component of marijuana, crosses the placenta, that maternal marijuana abuse results in intra-uterine growth retardation and that infants exposed to marijuana exhibit a temporary syndrome that includes lethargy and decreased muscle tone. Fetal exposure to THC can also result in attention deficits, learning disabilities and behavioral problems. "

Which probably will come as no surprise - either on a common sense level, or considering that another study found that endocannabinoids are significant in brain development.

LINK : www.physorg.com

 

[Guest]

I miss my rats

 

[Dantediv86]

why? did you give them too much THC?

i mean
these studies are really useless and stupid ANY mother knows that anything she takes during pregnancy is going to cause damage to the fetus!! i mean who would wash a wall with fresh paint on it?

 

[WetStaples]

Drugs and pregnancy do not go together. We shouldn't need studies to realize this. :lol:

 

[silv]

why? did you give them too much THC?

i mean
these studies are really useless and stupid ANY mother knows that anything she takes during pregnancy is going to cause damage to the fetus!! i mean who would wash a wall with fresh paint on it?

damn you, that's spot on! Washing a wall with fresh paint == big mess

 

[Brugmansia]

IMO every psychoactive or food abused by minors have significant side effects that do affect health or life-quality up to some degree.

Even excessive amounts of coffee at a young age can cause damage and hyper tension or agressiveness. This even goes for consuming the same nutrition daily over and over again.

Anyways, this study seems to be more confirmation on what we already know.

My own experience is that the benefits of THC are truly sensed when one smokes once every 2 weeks. Otherwise passiveness is easily onset while a reasonable time off assures that THC is a stimulant.

 

[GOD]

Give rats guns .

I read that when pregnant women eat vanilla their babys can taste it , and get a taste for it . Wich reminds me of junkie / addicted moms getting junkie / addicted kids . When i think about it it scares me a bit , that a babys life can be so easily conditioned , limited or controled by the things its mom does when she is pregnant . Then i start to think about the posibility that vanilla could have the genetic survival tactic of making us adicts to spread it around / asure its survival , cultivate it . A bit like a parasite that infects a life form and then invades its brain , changes its prioritys / behaviour to gain an advantage in its quest to spread / reproduce itself . Hepatitis also has an effect on a persons moods and maybe effects their intelligence . The one plant gets you high and through that garantees its survival , maybe its a wide spread tactic to cause mental effects in the host that magnify the parasites chances of survival . Are we realy free ?

 

[GOD]

I found this article on the subject :-

Marijuana + Alcoohol = Massive Brain Cell Death - In the womb

Marijuana is by far the most common illicit drug in the western world. However, pregnant women should be aware that this drug could affect severely the brain development of the children in their wombs. THC, the main active chemical of marijuana, enters into the fetal blood causing intrauterine growth retardation and a temporary syndrome comprising lethargy and lowered muscle tone, but also, on long term,attention deficits, learning disabilities and behavioral issues. A new research published in the Annals of Neurology points that THC, combined with alcohol, can cause massive brain cell death.

The team at the Neuroscience Research Center of the Humboldt University in Berlin and the Department of Pediatric Neurology, University of Technology, Dresden, Germany, exposed rats, 1 to 14 days old, to THC, a synthetic type of THC, ethanol, MK-801 (an anticonvulsant) and phenobarbital.

It was known that ethanol and drugs like sedatives, anesthetics and anticonvulsants caused massive brain cell death in the developing brain of immature rodents. The new study found that THC and its synthetic type did not induce neurodegeneration when administered alone, but it had this effect even when combined with low amount of alcohol non-toxic by itself. The effect was spurred gradually by increased doses of THC and was stronger in 7-day old rats. THC also boosted the neurotoxic impact of phenobarbital and MK-801 (which combined have the same effect as alcohol).

THC is known to act on CB1 receptors, inducing the psychomotor, memory, cognition and pain perception changes caused by marijuana consumption. THC, combined with alcohol, was found to have increased psychoactive effect, and the CB1 receptor blocker Rimonabant, an anti-obesity drug, decreased these effects. Mice lacking CB1 receptors were less vulnerable to the neurotoxic action of alcohol, thus these receptors could be the ones to induce the increased toxicity of the alcohol.

Previous researches had found that endocannabinoids (chemicals similar to cannabinoids (like THC and other chemicals in marijuana and hashish) synthesized by the human body) could boost cell multiplication and survival during the development of the central nervous system, explaining the age connection of the impact of THC/alcohol combination detected by this research.

"With the use of behavioral and stereological techniques such studies would explore whether acute changes reflect permanent neuronal loss and lead to behavioral deficits. The results of the acute studies have interesting potential therapeutic implications including the use of CB1 receptor antagonists for preventing brain damage in fetuses and neonates exposed to ethanol, sedative and/or anticonvulsant drugs," wrote the authors.

 

[Dantediv86]

*shiver*