MPTP bycicle day:
http://www.erowid.org/chemicals/mptp/mp ... try1.shtml
The substance has been found to metabolize in the brain
into a compound that kills midbrain dopaminergic cells whose axons project
to neurons in the basal ganglia. This produces clinical symptoms
essentially identical to those of parkinson's disease. The phenomenon was
first described in 1979 in the case of a 23-year-old graduate student who
had developed parkinsonian-like condition after using a meperidine-like
drug that he synthesized in his own laboratory. ... Unfortunatly, the
student was not the only one who used the adulterated substance, and
several dozen young users of this synthetic heroin [sic] have now
succumbed to a similar fate- a lifetime (which could be quite short) of
tremors, partial or complete paralysis, and abnormal posture."