Major negatives can become a problem if you use it often. It’s not the MDMA that you get a direct psychoactive effect from; rather it is the induced prolific serotonin (and a small degree of dopamine) release and reuptake that give you the effects; so once you’ve depleted your natural supply of these neurotransmitters, you wont be able to achieve any where near the same effects, if any at all. Also, serotonin breakdown by the MAO in your body does produce some bad by products, but nowhere near as bad as dopamine breakdown which produces hydrogen peroxide. So use it very sparingly, responsibly and only on very special occasions.
I do think it may have a small degree of therapeutic effect for anxiety, but very little if it’s a pronounced natural phenomenon in your psyche. Using it more frequently in conjunction with this kind of mental distress will make it worse over time. The comedown and day after negative effect is dependant on how much you took, if it was cut with any other substance, your diet and metabolism, set and setting etc... But all in all, used reasonably and in the best set and setting, MDMA is an awesome substance, with very little danger if used correctly and in moderation.
Also, that plastic love is kind of a placebo effect, because the serotonin release is a natural phenomenon, which is just sped up, increased in quantity and recycled more readily when you’re rolling. You can have a very deep experience on it and bond exponentially with people, and if you’re careful and not overindulgent, you have total clarity, equity and love.
Of course, if you need more information:
http://www.erowid.org/chemicals/mdma/mdma.shtml
Peace.[/url]