Goran.Hrsak a dit:
Space-is-the-Place
DMT can be used more times then Psilocin or Acid cause DMT action goes through 5HT-2c serotonine receptors against psilocin&Acid which use 5HT-2a serotonine receptors. This is why Acid and Shrooms have cross-tolerance!.
Peace
Light
Bless
well.. according to sources such as Riba and Nichols, DMT definitely goes through 2a receptors as a main pathway of action, so that can´t be the explanation why DMT shows no significant tolerance building.. In fact, studies have shown that 5HT2c plays a lesser role in the DMT experience because the 2c receptor gets gradually desensitized for DMT and 5HT2a remains the same, (and subjective experiences show no tolerance building, therefore 5HT2c is not as important even though DMT does have agonist properties at this receptor subtype)
So it´s more complex than that and I personally dont know why exactly it is this way