Just out of curiosity- poppers and Hawaiian Baby Woodrose?

[significationof?!?]

As I was reading about poppers, I learned that amyl nitrites are an effective treatment for cyanide poisoning...

Cyanide? Are cyanogenic glycosides not the gut-wrenching substances in Hawaiian Baby Woodrose? And so a lightbulb flashed: would amyl nitrites reduce the nausea (more of an intoxication if you ask me) of Hawaiian Baby Woodrose? And since they are vasodilatators, ease the muscle cramps a bit?
But are there dangers to this combination that someone with very little biochemistry knowledge such as me would not foresee?

Rest assured, I am not planning on trying this combination AT ALL, it is just out of curiosity that I am asking.

 

[Lion]

wow nice thinking man!
i'm quite curious about this myself too.
maybe i would even try it.
let's wait the comments

 

[achilless]

If I had to guess:

The duration of the effects of poppers are around 1 minute. If you would like to counter the nausea (in supposition that it would work), one should have a lot of hits to cover the time-laps were nausea occurs.
In addition (I can testify from personal experience) after only a few hits of poppers, they cause you to have got HEADACHES and nausea.
Conclusions ?

 

[Lion]

poppers don't give headaches.
you shouldn't snort the bottle in one time.
i've had loads of experience with this while on acid.
i think it depends on person wether you get sick from it. but start slowly and build your way up then it's handable i think.
but beware, too much snorting poppers will give you a strong cold the next day.

 

[significationof?!?]

Well amyl nitrites don't reduce nausea; they "induce the formation of methemoglobin. In cases of cyanide poisoning, the methemoglobin combines with the cyanide to form nontoxic cyanmethemoglobin. Amyl nitrite vapours are absorbed rapidly through the pulmonary alveoli, manifesting therapeutic effects within one minute after inhalation. The drug is metabolised rapidly, probably by hydrolytic denitration; approximately one third of the inhaled amyl nitrite is excreted in the urine." (Medsafe).

So a single amyl nitrite popper would very quickly transform the cyanide into cyanmethemoglobin, but I don't know if that is any better nausea-wise, only that it is an effective treatment for life-threatening cyanide poisoning.

Anyway, the attribution of the nausea from HBW seeds to cyanogenic glycosides is simply a very probable (and very widespread) hypothesis based on the presence of cyanogenic glycosides in the seeds of many other plants in the rose family. The presence of other ergot alkaloids is probably responsible for part of the nausea, in my opinion; anyone who has experience with properly extracted alkaloids from HBW can comment on this?

Here's what Wiki says on cyanogenic glycosides: "[...] the glycoside can release the poisonous hydrogen cyanide if acted upon by some enzyme. An example of these is amygdalin from almonds. Cyanogenic glycosides can be found in the fruits (and wilting leaves) of the rose family (including cherries, apples, plums, almonds, peaches, apricots, raspberries, and crabapples)."

Lion, since you have had loads of experience with LSD and poppers, would you say that this combination has risks that neither of the substances alone have? Is the whole trip LSD affected by the amyl nitrites, or only for a short time?

 

[Lion]

my experience with this is:
when you use poppers during the entire LSD trip the trip will get influenced. But not in a bad way. depends on how you look at it. your trip will get more narrowminded. you can only focus on one thing at the time. which causes spirals. time FLIES by. the feeling of the poppers dominates for a brief second. just untill the rush is over.
a bad effect on it is that the poppers make you go dumb. you practically won't even notice you're in a trip.

but lsd has nothing to do with cyanide poisening.
so i'm curious what these 2 combined may cause

 

[Brugmansia]

I did them while being high on cannabis, all the extended thoughts were gone. And it felt like I was promptly back to sober with my vision and physique. The heartbeats were readily gone after sniffing.

I don't know, it's not particulary a narrow minder itself, but it may break down mind expanded effects of other psychoactives.

Perhaps something to remind if you're going really bad. Although you'd have to sniff every 3 minutes, lol. I never had any headache either after repeated use. But it noticeably did affect my short-term memory. And I don't like that.