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Health workers and interested individuals have expressed concerns about the use of Viagra in combination with MDMA. This use was not covered by the FDA approval research process for Viagra. In fact, neither the FDA nor NIDA require any evaluation of pharmacological interactions of new drugs with commonly-used recreational substances. While little to nothing is known about any specific interactions, there are several health concerns which could pose potential problems for those who combine these two substances:
Heart issues
Perhaps the most dangerous possible interaction between Viagra and MDMA is the theoretical risk that Viagra's vascular effects could interact dangerously with MDMA's heart-rate, blood pressure, and body temperature-increasing tendencies. MDMA is a strong stimulant, increasing heart rate, blood pressure, and body temperature. Sildenafil, on the other hand, is a vasodilator and reduces blood pressure systemically.1
Although it is inappropriate to assume that a vasodilator 'cancels out' the effects of a stimulant, there is currently no indication that combining these two substances increases the cardiovascular risk of the other. Each substance on its own poses substantial medical risks to those with heart conditions.
Priapism
The other major concern with this combination is possibly increasing the risk of penile injury from long-lasting erection (called priapism). There are cases reported in the medical literature of sildenafil, by itself, resulting in priapism. 4It has been suggested that Ecstasy users might take unusually high doses of Viagra out of poor judgment or because they believe they need more to overcome the effects of the MDMA. It is possible that higher doses could be associated with increased priapism or other health risks. Also, there is speculation that there could be an interaction between MDMA and sildenafil because of MDMA's heavy 5-HT (serotonin) activity.
Although there have been quite a few reports of men combining the use of ecstasy and Viagra, as of March 2012, there are no medical case reports published in the scientific literature for priapism resulting from the combination. There are two cases mentioned without details at ecstasy.org, but we have not been able to find any further information about this claim. There is a case report in which a doctor speculates that priapism could be associated with Ecstasy alone. In a 2009 paper based on interviews of recreational drug users in "the club scene" in Australia Addiciones, "One participant reported 'soreness' from being erect for an extended period of time (priapism)."3 However it is not obvious from this response that actual medical priapism occurred, since soreness from sildenafil-ecstasy extended sex is common.
As of March 2012, it appears that combining MDMA with sildenafil does not substantially increases the risk of priapism, but those who choose to take either or both of these substances should pay attention to potential problems and seek medical attention quickly if their erections last longer than a few hours. Priapism can cause permanent injury resulting in reduced ability to achieve erections in the future.
Ouroboros a dit:J'etais ironique en te disant que tu pouvais faire confiance gros ^^