I'm really surprised how people are combining OTC's to combat their side-effects. Folks take a particular drug that makes them "trip", but then they have to take all kinds of other substances against the diarrhea, nausea, drowsiness, rash etc.
Milk Thistle is a wonderful plant. It protects, purifies and repairs the liver. It's best taken after the use of toxic drugs. Milk Thistle is so powerful, it's even an antidote for poisoning by the Death Cap (Amanita phalloides).
Better skip the toxic drugs though, and use the Milk Thistle for its high content of antioxidants and to keep your liver in good shape.