J'ai quand même d'énormes doutes sur la présence d' IMAO dans un tel cactus:
-Les IMAO ne sont pas franchement les molécules synthétisés par les cactus
-Les différents alcaloïdes des cactus ne sont pas dégradé principalement et très vite par les MAO, donc un IMAO ne rendrait pas forcément actives ces molécules (au contraire de la DMT)
Après, les études sur ces cactus ont principalement trouvé des tetraisoquinolines, peut être que ces dernières possèdent une activité d'elles même? En synergie?
Sinon, de ce que j'ai pu voir que shulgin disait:
" A good example is a relatively unexplored columnar giant called Pachycereus pringlei. In the published literature, there have been five compounds reported as being present. I have seen four of these, and have obtained mass spectra of 18 additional compounds. Some of these new components I have already identified, but none of these is known to be active in man. And yet I know that the cactus is active as I have actually eaten it and have gotten real effects. Could this be an example of a plant that contains two compounds that are active in combination whereas neither one is active as an isolated chemical? Such things are known in nature. "
de:
http://www.cognitiveliberty.org/shulgin/adsarchive/future_psychedelic.htm
Il ne parle pas franchement d'IMAO! Et il ne faut pas oublier que l'intérêt de shulgin pour des molécules nouvelles peut être avant tout scientifique, avant d'être utile pour les psychonauts.
D'ailleurs, on peux lire son expérience:
"JUST AFTER sunset on a cool California evening last fall, Alexander Shulgin prepared to test the effects of the cactus Pachycereus pringlei on himself, his wife, and 10 other subjects. The group, which included two chemists and an anthropologist, gathered in the living room of a redwood house deep in the woods to help Shulgin with his research into psychedelic cacti. A few months earlier, the anthropologist had told Shulgin that this particular variety was worth looking into - a cave painting in Mexico suggested it might have psychoactive properties. Through chromatography, Shulgin determined that P. pringlei probably was a mild psychedelic, but "the establishment of its human pharmacology requires that it be consumed by man." So Shulgin dissolved the extract of the cactus into fruit juice, then poured a 4-ounce cup for each person. But his experiment went awry. "At about the two-hour point, my visual experiences became totally swamped by an overwhelming fear of moving," recalls Shulgin, the 77-year-old chemist who introduced ecstasy to the world. His wife, Ann, had an even more severe reaction. Out on the deck, she remembers, "I could see the full moon shining down on me with what felt like chilling contempt, and I thought, What an awful, stupid way to die." With her pulse racing, she went inside to check on her husband, who was upstairs in one of the bedrooms, lying still in the dark. "He said he was OK as long as he didn't move." Early the next morning, Shulgin assembled his test group, still in pajamas, to assess the effects of the cactus extract. All 12 of them had taken the same compound, but half had become violently ill, while the other six had the kind of pleasant but unremarkable experience Shulgin expected. The results, he decided, were inconclusive."
De :
http://www.mdma.net/alexander-shulgin/professor-x.html
Ca n'a pas l'air très réjouissant! Mais tu peux tenter l'expérience et venir nous faire part de tes résultats![/u]
