Yes. They share some effects so I would only use a single combined dose (ex. a half dose of each instead of a full dose of each). Start low and work up, playing it safe, as with any drug, especially research chemicals, and especially with combinations you haven't tried.
Have fun and tell us how it works.
By the way, thought you should know I haven't done this combination myself, but there are some trip reports of people doing that combination, and my friends have played around with combinations of the 2c-X chemicals.
Be safe, start small, and you'll probably have a very interesting experience.